抄録
Osmotic fragility test of erythrocytes by coil planet centrifuge was studied in 33 patients of iron deficiency anemia, 9 of polycythemia vera, 8 of hemolytic anemia (hereditary spherocytosis 5, autoimmune hemolytic anemia 2, paroxysmal nocturnal hemoglobinuria 1), 7 of acute leukemia, 6 of aplastic anemia, 6 of malignant lymphoma, 3 of multiple myeloma, and 3 of SLE.
In 35 healthy adults, lysis of erythrocytes began at 101.4±4.8 mOsM and completed at 59.1±2.6 mOsM.
In iron deficiency anemia osmotic fragility was within normal range. The peak of osmotic fragility curve (HMP) was shifted to the left with improvement of anemia.
In hemolytic anemia osmotic fragility of erythrocytes always increased. In autoimmune hemolytic anemia the good correlation between erythrocyte osmotic fragility and reticulocyte counts. Osmotic fragility tended to be normalized when their hemolytic signs and symptoms improved.
In acute leukemia osmotic fragility increased in pre-treated or relapsed stage and normalized in remission.
In SLE marked increase in osmotic fragility was found in active stage and returned to normal in inactive stage.
In multiple myeloma osmotic fragility showed remarkable increase.
