抄録
A 27-year-old male first presenting as hematologically typical CML with Ph1 chromosome and low NAP score, developed acute transformation four years after the diagnosis. In the terminal phase, the number of promyelocytes identified by may-Giemsa stain and electron microscopy, reached 62.5% of 598,000/mm3 of white blood cells in the peripheral blood. Bone marrow aspirate showed hypercellular features with 32.0% promyglocytes. A remarkable hemorrhagic tendency with reduced ESR and positive FDP appeared after DCMP treatment.
Autopsy revealed hypoplastic marrow with increased reticulum cells, the presence of petechiae, thrombus formation and hemorrhagic infarction in various organs and systemic mucormycotic infection.
