抄録
An investigation was made on 23 aspects of blood coagulation, including 1) screening tests, 2) coagulation factor activities and 3) platelet function tests in 35 cases of ulcerative colitis and 19 cases of Crohn's disease using a classification of increased and decreased coagulability. Of the 35 cases of ulcerative colitis, 2 severely affected cases were accompanied with disseminated intravascular coagulation syndrome (DIC) and 1 died after emergency surgery.
Increased fibrinogen content, factor VIII, IX activity and platelet count, accelerated platelet aggregation and retention rate were found in many cases of active stage of the disease. At the time of remission, this hypercoagulability was generally normalised in many cases, but still remained in a few cases.
From above results, most cases of the disease showed definite signs of hypercoagulability. When marked hypercoagulability and DIC are present, anticoagulant therapy should lead to a favorable effect.
