抄録
Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) activities were measured with the lymphocyte fraction from patients with various lymphoproliferative disorders. The ratio of ADA activity to PNP activity (ADA/PNP) was high in T-cell malignancies including T-cell chronic lymphocytic leukemia, adult T-cell leukemia, Sézary syndrome and T-cell lymphosarcoma and one case with null cell lymphosarcoma. The values determined in other lymphoproliferative disorders and nonlymphocytic leukemias were low and equivalent to the values (<1) obtained in nomal controls. These results suggest that undifferentiated T-cells have high ADA/PNP ratios and higher values indicate more undifferentiated T-cell malignancies.
