抄録
A 29 year-old woman was admitted to our hospital because of ovarian bleeding and diagnosed as von Willebrand's disease in 1978. Subsequently she suffered from ovarian bleeding twice in 1979 and in 1981. At the 3rd bleeding episode, enlarging hematoma was palpable in her right lower abdomen, and she was treated with DDAVP as follows.
Twenty μg of DDAVP was added to 100 ml of isotonic saline and administered by drip infusion intravenously over 20 to 30 minutes. For one to four hours after infusion, factor VIII complex showed marked increase as compared with its basal level: VIIIR: AG increased from 30% to 86%, VIIIR: WF from 37% to 100%, VIII: C from 7.2% to 33%. This treatment was applied every 12 hours for five days. Subsequently the hematoma was diminished in size and disappeared two weeks after the treatment. DDAVP was regarded as useful for hemostatic control of von Willebrand's disease.
