抄録
Nine cases of histiocytic medullary reticulosis in childhood were studied. Ages ranged from 10 months to 13 years-5 months with median 2 years-11 months and four cases were male. Bone marrow smears, obtained on admission and periodically during the treatment, were stained with Wright-Giemsa. Marrow histio-monocytes were classified according to the definition of Manoharan, depending on the degree of maturation and phagocytic activity. Histio-monocytes were graded from I through V, and pre-treatment distribution patterns were compaired for the nine cases, which resulted in two distinct groups: A (n=5) and B (n=4), respectively. Group A demonstrated higher percentage of immature I and II type cells (32.6±3.8%); by contrast, group B was characterized by lower I and II type cells (13.3±4.2%). Follow-up of marrow histio-monocytes studied in some cases during the course of treatment reflected the tumor activity. In spite of the fact that the two groups could not be clearly categorized by clinical symptoms and signs, and routine laboratory procedures, the four cases in the group A responded poory to the induction chemotherapy, with one CR, two PR, one NR and one died before treatment. On the other side, all four cases in the group B achieved CR. In these nine cases, determination of the pre-treatment distribution patterns of marrow histio-monocytes was significantly useful in predicting the prognosis of histiocytic medullary reticulosis in childhood.
