免疫不全と悪性リンパ腫の発症

抄録

Recently it is accepted that immunodeficiency such as congenital immunodeficiency, autoimmune diseases and organ transplant recipients are associated with a high risk of malignancy, especially malignant lymphoma. Therefore, relationship between immunodefiency and the development of malignant lymphoma has been attracted attention. But in Japan reviews concerned with this problem have been seldom reported probably because of poor attention.
Author experienced eight cases of malignant lymphoma occurred subsequent to autoimmune diseases and feel that such cases are not rare, so the development of malignant lymphoma associated with immunodeficiency is reviewed from literatures to attract attention.
Ninety cases of malignant lymphoma occurred during course of autoimmune dieases were summed up from literatures and questionaire and analysed. Results were as follows: 1) Collagen diseases (especially Sjögren's syndrome and SLE) were most frequent as basic autoimmune diseases. 2) Cases treated with immunosuppressive agents were unexpectedly few. 3) When malignant lymphoma occurred, in about half basic autoimmune diseases got better.