A case of Hodgkin's disease associated with pure red cell aplasia (PRCA) is reported. A 19 years old male was admitted because of anemia, cervical lymphadenopathy, and hepatosplenomegaly in June 1983. Microcytic normochromic anemia with reticulocytopenia (1‰) was observed without evidence of hemolysis. Bone marrow puncture of sternum showed only depletion of the erythroid tissue and no malignant cell was observed. The diagnosis of Hodgkin's disease (LD) was confirmed by cervical lymphnode biopsy and the disease was classified into stage IVB as the result of ileal bone marrow biopsy. He achieved complete remission (CR) with the administration of VEPA (vincristine, Endoxan, prednisolone, Adriacin) therapy. In the coincidence with CR, normal erythropoiesis recovered and PRCA disappeared. On December 1983, he was admitted to the hospital because of relapse. Despite of several courses of various combination chemotherapy and radiation therapy, he did not achieve remission and died on August 1984. At autopsy, thymoma was not seen. The pt's serum obtained during PRCA did not inhibit the growth of CFU-E colony from normal bone marrow.