症例
著明なHistiocyteの増生を伴ったT Cell Lymphomaの1例
1986 年 27 巻 2 号 p. 225-230
詳細
1986 年 27 巻 2 号 p. 225-230
An autopsy case of T cell lymphoma with marked proliferation of histiocytes is reported.
A 1-year-4-month old female developed fever, skin rash, hepatosplenomegaly and pancytopenia. Despite extensive chemotherapy, the condition was rapidly deteriorated and died 3 month after the initial symptoms due to multiple intestinal ulcers and perforations.
At autopsy, marked infiltration and proliferation of blastic cells intermingled with phagocytic cells were found in the lymphnodes, liver, spllen and bone marrow. The histological feature was typical of malignant histiocytosis (MH). Further investigations with immunohistochemical and cytochemical techniques demonstrated that blastic cells had the character of activated T cells, whereas the phagocytic cells were shown to be macrophages of mononuclear phagocytic system.
The collective evidence indicates that the present case may fall into the category of T cell lymphoma associated with the marked increase in cytophagocytic macrophages.
The possible interraction between neoplastic T cells and macrophages is discussed.
