シンポジウム3．
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
分子生物学的立場からみた慢性骨髄性白血病とその類縁疾患の検討
1988 年 29 巻 7 号 p. 1010-1017
詳細
1988 年 29 巻 7 号 p. 1010-1017
Molecular biologic study was performed in 30 cases of chronic myeloproliferative disorders (MPD). According to the study dealing with breakpoint cluster region (bcr) rearrangment, 10 of 11 cases of Ph1(+) chronic myelogenous leukemia (CML) had bcr rearrangement, whereas 2 of 5 Ph1(-) CML had the change. On the other hand, other MPD, including 8 cases of polycythemia vera, 2 myelofibrosis, 2 essential thrombocythemia and 1 undifferentiated MPD didn't show bcr rearrangement. These data strongly suggest that bcr rearrangement is a characteristic change for CML in MPD, and a heterogeneity might be present in Ph1(-) CML; some show bcr rearrangement and others do not. This molecular biologic heterogeneity might be related to clinical features in Ph1(-) CML.
