シンポジウム3．
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
Variant Ph1陽性慢性骨髄性白血病ならびに分類不能型骨髄増殖性疾患の解析
1988 年 29 巻 7 号 p. 1018-1024
詳細
1988 年 29 巻 7 号 p. 1018-1024
The bcr rearrangement in bone marrow and/or peripheral blood cells was examined in followings; 30 standard Philadelphia chromosome-positive chronic myelocytic leukemia (Ph1+CML), 2 variant Ph1+CML [t(9;22;13)(q34;q11;q22), t(9;22)(q21;q11)], 3 Ph1+ acute leukemia, one myelofibrosis (MF), 5 polycythemia vera (PV), 6 essential thrombocythemia (ET), 2 juvenile CML (JCML), 2 chronic neutrophilic leukemia (CNL), 4 chronic myelomonocytic leukemia (CMMoL) and 3 unclassified myeloproliferative disorders (UMPD) patients. By Southern blot analysis using a 3'bcr probe, the bcr rearrangement was positive (bcr+) in 28 standard Ph1+ CML, and 2 variant Ph1+ CML, whereas negative in MF, PV, ET, JCML, CMMoL and UMPD, suggesting that the bcr rearrangement is highly specific for CML and valuable for the diagnosis of this disease. One Ph1+ bcr+ acute leukemia was thought to be blast crisis of CML with a silent chronic phase.
Further studies on UMPD are necessary in order to clarify the relations of MPD, Ph1- CML and some myelodysplatic syndromes.
