Chromosomes and surface markers in cells of the lymphnode in two patients with immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma were examined before intensive chemotherapy. In patient A, the cell markers study demonstrated the presence of monoclonality of T-cells and chromosome analysis showed some abnormalities such as trisomy #3 or ring chromosome. In patient B, although the surface marker study failed to demonstrate monoclonality of B- or T-cells, chromosome analysis showed an abnormal clone with trisomy #3 and t(3;7)(q12;q32).
From the cytogenetic aspects, the significance of chromosomal abnormalities in IBL like T-cell lymphoma was discussed in reference to the literature.
