A 36-year-old female was admitted to our hospital because of headache and swelling on left leg in April, 1986. She was obese and drowsy due to marked dehydration and hyperglycemia. Thrombosis of inferior vena cava and collateral circulation were demonstrated by RI angiography and venography. Coagulation studies revealed a consumption coagulopathy; namely low platelet count and fibrinogen level, and elevated FDP, D-dimer and fibrinopeptide A. However, the level of antithrombin III, protein C, protein S and plasminogen were normal. Following urokinase and heparin infusion, her general condition and laboratory data improved gradually. Then, warfarin was administered, but she was suffering from pulmonary infarction. In order to prevent fatal pulmonary embolism, inferior vena cava filter was implanted with clinical improvements.
