抄録
Eighty-seven patients were divided into two groups such as coronary heart disease (CHD) and non-CHD by the method of coronary angiography. High density lipoprotein-cholesterol (HDL-TCh), very low density lipoprotein total cholesterol/trigryceride (VLDL-TCh/TG) and β-K band were measured in all of the patients after the experimental diet treatment. HDL-TCh in the CHD was significantly lower than that in the non-CHD group, P<0.001. There were, however, no correlation between HDL-cholesterol concentration and the location of coronary arterial stenosis. HDL-TCh and VLDL-TCh/TG were related with the grade of coronary arterial irregularity. An increased grade of the irregularity was accompanied with the lower concentration of HDL-TCh, and the higher ratio of VLDL-TCh/TG. A frequency of the β-K band was significantly higher in the CHD (45.9%) as compared with that in the non-CHD (12.1%). Particularly, twenty-two patients with the irregural coronary artery were showed 68.1%, whereas the patients without the irregularity were only 13.3%. A negative relation between HDL-TCh and VLDL-TG was found in the non-CHD, whereas the CHD was r=0.444.
These results might be of interest in the view of HDL-cholesterol as a well documented and dependent “irregularity of coronary artery.” And this is based on a lipoprotein metabolism correlating between HDL and VLDL fraction. In this investigation a clinical significance of HDL-cholesterol for coronary heart disease has been studied. Particularly, a relationship between the conformation of coronary artery and HDL-TCh was discussed.
