Effects of radiation on serum proteins in rabbit

Abstract

Time sequential changes of various serum protein fractions of rabbits irradiated in a single dose of 800R of ⁶⁰Co γ-ray, were evaluated by electrophoresis, immunoelectrophoresis and single radial immunodiffusion. The results are as follows;
(1) The increase of serum albumin level was observed immediately after irradiation. However, serum albumin level decreased significantly afterwards. On the statistical analysis, significant correlation between serum albumin level and other protein fractions was recognized.
(2) The significant decrease of α₁-globulin level was encountered immediately following irradiation.
(3) Time sequential changes of serum α₂-globulin were opposite to those of serum albumin level.
(4) The significant increase of β-globulin was recognized for certain period following irradiation.
(5) The day of irradiation significant decrease of serum γ-globulin level was obtained in immediate and first day after irradiation.
This phenomenon was thought to be related to IgG value.