22 巻 (1988-1989) 4 号 p. 229-235
The sensory irritation such as biting appears after application of cosmetics. This irritation is the passing stimulation without inflammation. We investigated many cosmetic materials, and made researches on the substance and mechanism of this stimulation.
In the results, the sensitivity among the population showed the individual differences. The intensity of irritation is directly related to the number of molecules, is effected by temperature and viscosity of vehicles.
We considered that the causative substances must have the high affinity to the skin. This high affinity is dependent on suitable molecular size, polarity, structure and electronic property of the molecule.
The detail of this stimulation was reported.