The main purpose of this study is to reveal the stress reduction in respiring the air of 30% oxygen concentration. The following two studies were investigated by using a device "Oxygen Air Charger" which supplies enriched oxygen air. 1) During driving an automobile, the enriched oxygen made significant effects on the brain activity. 2) In the group burdened with valid stress breathing the enriched oxygen, the skin-barrier function recovered significantly compared with the group breathing the normal air. These two results indicated that the stress could be reduced by respiring the air of 30% oxygen concentration.