We developed a numerical method which simulates combined heat and water vapor transfer processes in solid desiccant materials. It can evaluate moisture adsorption and desorption to the materials and their heat generations. Firstly, we measured the adsorption isotherm and moisture transfer coefficient of the desiccant rotor which have a great effect on the performance of dehumidification. Secondary, in order to validate the numerical calculation method considering the wheel's rotation, we compared the calculation results with the experimental results for an actual desiccant machine.