3 家兎VX2癌の微細血管系に及ぼすトラネキサム酸の影響に関する研究 (第432回 大阪歯科学会例会)

抄録

I investigated the effect of the antifibrinolytic agent tranexamic acid on tumor growth and vacularization. VX2 carcinoma cells were implanted into the ears of rabbits. Tranexamic acid (2,000 mg/kg) was administered daily by femoral intramuscular injection in the experimental group. Tumor growth was suppressed in the experimental group compared with the controls which received no injection. Examination of the microvascular structure revealed that tumor angiogenesis was delayed in the experimental group. Further capillary networks were constructed throughout the entire tumor region after two weeks, but were loose compared with the controls. These results suggest suppression of tumor growth in the VX2 carcinoma resulted from inhibition of tumor angiogenesis by the tranexamic acid.