3 抜歯創治癒過程におけるbasic Fibroblast Growth Factor (第439回 大阪歯科学会例会)

抄録

In order to elucidate the effect of basic fibroblast growth factor (bFGF) on the healing process after tooth extraction, I investigated the localization of bFGF, FGF-receptor (FGF-R) and alkaline phosphatase (ALP) activity, and studied new bone formation in the socket by laser scanning microscopy (LSM). Angiogenesis with intense localization of bFGF was initiated three days after extraction and new bone formation was evident by LSM after 7 days. Localization of ALP activity and FGF-R increased gradually with time from the socket bottom toward the surface. These results indicated that the greatest decrease in bFGF result from consumption by fibroblasts, followed by consumption by endothelial cells and osteoblasts in that order. In other words, the amount of FGF-R tended to increase, along with increasing ALP activity. After that, osteoblasts promoted bone formation.