Abstract
We studied on the toxicity of tetrodotoxin of Fugu which was imported to Japan, by use of mice and the following results were obtained:
1) Crystalline tetrodotoxin exhibited the strongest toxicity in mice by intracerebral injection. The degree of toxicity by administration routes was expressed by the following order: intracerebral, intravenous, intraperitoneal, subcutaneous and oral.
2) The dose of toxin corresponded to the death time.
3) The toxicity of tetrodotoxin was decreased by the addition of tissue homogenate of Fugu (tetrodon).
4) Nashi-Fugu, and Nagoya-Fugu were not so toxicic as other Fugs.
