Growth-lnhibition of Baker's Yeast by Cationic Surface-Active Agents (II)

Correlation between Adsorption of surface-Active Agents on Yeast-Cells and Growth-lnhibition of the Yeast

Abstract

Adsorption of germicidal quarternary ammonium salts on yeast-cells and their effects to growth of the yeast were simultaneously observed by the authors' method.
1) Lauryldimethyl-β-hydroxyethylammonium salts which consist of different kinds of anions, were shown to have no significant difference among the compounds both in their adsorption and growth-inhibition.
2) Both a) alkyldimethylbenzylammonium salts and b) alkyldimethyl-γ-chloro-β-hydroxypropylammonium salts indicated the tendency of lncreasing adsorption on yeast-cells in accordance with the increase of alkyl chain-length from lauryl to stearyl. Growth-inhibition of the yeast, by a) type compounds, was proved to be approximately proportional to the chain-length, whereas the growth-inhibition by b) type compounds was shown to be contrary to the chain-length.
3) Among 5 kinds of lauryldimethylammonium chlorides which contain benzyl or alkyl radicals, γ-chloro-β-hydroxypropyl compound was proved to be the highest both in adsorption on yeast-cells and growth-inhibition. The growth-inhibition of yeast was observed by other compounds in a descending order of benzyl, β-hydroxyethyl, methyl and β-hydroxypropyl radicals.