Bowen病病変部に生じた小結節がMerkel cell carcinomaであった1例

抄録

A 82-year-old male patient with Merkel cell carcinoma (MCC) associated with Bowen's disease was reported. The patient developed a clearly demarcated tumor 14×17×3mm which has erythematous plaque 22×30mm at the flexor surface of the right thigh. Histologically, the epidermis showed Bowenoid changes. There were tumor nests consisting of round and oval cells in the dermis. Atypical nuclei and mitoses were markedly seen, with a trabecular pattern. Immunohistochemistry revealed positivity to NSE. Electron microscopically, dense core granules and intermediate filaments were observed. Based on these findings, the diagnosis was made.