抄録
We describe a 66-year-old woman with a 3-week history of erythema and bulla on her soles. She had received MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, predonisolone, bleomycin) therapy for non-Hodgikin's lymphoma. The skin lesion improved after three weeks without stopping the chemotherapy. Histological examination showed many necrotic keratinocytes, irregularly elongated rete ridges, vacuolar alteration in the basal layer, and perivasucular neutrophilic and lymphocytic infiltration in upper demis. These findings suggested a toxic reaction to epidemis induced by MACOP-B therapy. [Skin Cancer (Japan) 2000; 15: 79-84]
