Roles of Adenosine Diphosphate and Creatine Kinase in Myofilament Dysfunction in Diabetes

James T. Pearson; Hirotsugu Tsuchimochi; Takashi Sonobe; Mark T. Waddingham; Pei Chen Connie Ow; Vasco Sequeira

doi:10.18957/rr.12.1.12

Section A

Roles of Adenosine Diphosphate and Creatine Kinase in Myofilament Dysfunction in Diabetes

James T. Pearson, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T. Waddingham, Pei Chen Connie Ow, Vasco Sequeira

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Keywords: actin-myosin filaments, cross-bridges, cardiac muscle, contractility, 2018A1127, BL40XU

JOURNAL OPEN ACCESS

2024 Volume 12 Issue 1 Pages 12-16

DOI https://doi.org/10.18957/rr.12.1.12

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Abstract

　We investigated in prediabetic rats the effect of creatine kinase inhibition on myosin mass transfer to actin filaments in the in situ heart with SR small-angle X-ray scattering. We established a role for ADP in increasing myosin S1 head proximity to actin filaments during diastole but suggest elevated ADP does not contribute to impaired cardiac muscle relaxation in the early stage of prediabetes.

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