Renin-Angiotensin System Role in the Pathophysiological Progression of Coronary Dysfunction in Prediabetic Female Rats

Patrick Meagher; Yi Ching Chen; Hirotsugu Tsuchimochi; Lucinda M. Hilliard; Katrina M. Colafella; Keiji Umetani; Mikiyasu Shirai; Robert E. Widdop; Kate Denton; James T. Pearson

doi:10.18957/rr.8.3.473

Section A

Renin-Angiotensin System Role in the Pathophysiological Progression of Coronary Dysfunction in Prediabetic Female Rats

Patrick Meagher, Yi Ching Chen, Hirotsugu Tsuchimochi, Lucinda M. Hilliard, Katrina M. Colafella, Keiji Umetani, Mikiyasu Shirai, Robert E. Widdop, Kate Denton, James T. Pearson

著者情報

Patrick Meagher
Monash University
Yi Ching Chen
Monash University
Hirotsugu Tsuchimochi
National Cerebral and Cardiovascular Center Research Institute
Lucinda M. Hilliard
Monash University
Katrina M. Colafella
Monash University
Keiji Umetani
SPring-8/JASRI
Mikiyasu Shirai
National Cerebral and Cardiovascular Center Research Institute
Robert E. Widdop
Monash University
Kate Denton
Monash University
James T. Pearson
Monash University
National Cerebral and Cardiovascular Center Research Institute

キーワード: angiotensin-II receptors, vasodilation, endothelium, diabetes, 2014B1154, BL28B2

ジャーナルオープンアクセス

2020 年 8 巻 3 号 p. 473-475

DOI https://doi.org/10.18957/rr.8.3.473

詳細

抄録

We investigated in female rats the coronary response to infusion of angiotensin-II type 2 receptor agonist compound 21 (C21) utilizing high resolution SR microangiography. We found that in non-diabetic rats acute C21 infusion evoked dilation in the coronary microvessels that most likely involved endothelium derived hyperpolarization factors, while C21 evoked mild constriction in prediabetic rats.

責任著者(Corresponding author)

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