メソポーラスシリカSBA-15に対するビタミンEの貯蔵・放出特性

抄録

One of the industrial applications of mesoporous silica is drug delivery since there is a possibility that the uniform mesopores can control storage and release of medicinal substances. In the present work, SBA-15 was selected as a candidate for the drug delivery carrier, and the effect of the pore size decreased by grafting propyl and octyl groups on the storage and release of vitamin E whose antioxidative ability is efficacious against diabetes, cardiovascular diseases and so on was investigated. N₂ adsorption isotherm at 77 K verified that the octyl group reduced the pore size more than propyl group. Vitamin E soluble in ethanol was accommodated into pore channels under ambient condition, but an amount of the accommodated vitamin E decreased with pore size of the employed carriers. On the other hand, the release ratio of the accommodated vitamin E in ethanol increased with the decrease in the pore size. Based on the experimental results mentioned above, location model of vitamin E in the pore channels was discussed for the neat and the grafted carriers. Furthermore, the accelerated oxidization of linseed oil was operated at 373 K in the presence of the neat carrier to evaluate the controlled vitamin E release.