抄録
Drug delivery system improves the efficacy of drug by the enhancement of absorption, controlling the body distribution and etc. This review reports the design method for drug delivery system with polymeric nanoparticle by surface modification. The fate of nanoparticle depends on the surface properties such as electrical charge, hydrophobicity as well as particle size. By modifying nanoparticles with polysorbate 80, the distribution percentage and retention time of nanoparticle in the brain tissue increased. By the modification with chitosan to provide positively charges, the cellular uptake of nanoparticle was increased. According to these results, the surface modified nanoparticulate system with the suitable material could deliver the drug more efficiently to the required tissue compared to the conventional dosage forms.
