抄録
New toxicity testing method using in vitro assays and in silico models as an alternative approach to animal testing has been rapidly evolving in the past few years. PBPK model is a powerful tool which can relate the results from in vitro assays to the exposure scenarios by calculating biologically effective dose. Age-Dependent Biologically Effective Dose Evaluation System calculates the biologically effective dose of general Japanese population using PBPK model. In this study, we have evaluated the result and re-consider the estimation method for partition coefficient.
