Spine Surgery and Related Research
Online ISSN : 2432-261X
Clinical Outcome and Prognostic Factors of Malignant Spinal Dumbbell Tumors
Yoshihiro MatsumotoKenichi KawaguchiJun-ichi FukushiMakoto EndoNokitaka SetsuKeiichiro IidaSatoshi BabaHirokazu SaiwaiAkinobu MatsushitaMitsumasa HayashidaSeiji OkadaYasuharu Nakashima
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2018 Volume 2 Issue 4 Pages 317-323


Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs).

Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome.

Results: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS.

Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.

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© 2018 The Japanese Society for Spine Surgery and Related Research. CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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