Abstract of annual meeting of the Surface Science of Japan
[volume title in Japanese]
Session ID : 3Da08
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Characterization of Molecular Behaviors on Phospholipid Membrane Surface based on Membrane Surface-Enhanced Raman Spectroscopy Method
*Keishi Suga
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Abstract
We describe the membrane surface-enhanced Raman spectroscopy (MSERS) using phospholipidmodified Au nanoparticles (Au@PL), and report the properties of the self-assembled PL membranes on the Au nanoparticle. The Raman intensity per PL concentration increased by 50-170 times with Au@PL, depending on the aggregation degree of Au@PLs. The enhancement at 714 cm-1 (EF(714)) varied with the hydrocarbon chain length of the PLs and the assembleddegree of Au@PLs. In calculation, the EF(714),assembled was estimated to be 111-142 when the distance between AuNPs was 7.0-7.5 nm, which was correlated to the speculative enhancement factor, suggesting that the assembly of the Au@PLs contributed to the MSERS. We prepared the DC-cholesterol modified Au nanoparticles (Au@PL), and applied them to induce the complex formation with small nucleic acid such as tRNA, amyloid beta peptide.
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© 2018 The Surface Science Society of Japan
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