科学・技術研究
Online ISSN : 2187-1590
Print ISSN : 2186-4942
ISSN-L : 2187-1590
原著
Bioavailability of dietary antioxidants in Acanthopanax sieboldianus Makino leaves
Tomoko UenoHiroyuki NodaTateaki Ogata
著者情報
キーワード: LC/MS, metabolism, MS/MS, polyphenol, Ukogi
ジャーナル フリー

2013 年 2 巻 1 号 p. 35-42

詳細
抄録
We have investigated the intestinal absorption and metabolism of the polyphenols contained in Acanthopanax sieboldianus Makino (Ukogi in Japanese) in rat plasma using a liquid chromatography/mass spectrometry (LC/MS). Ukogi mainly contained chlorogenic acid, rutin, and kaempferol 3-O-rutinoside. These polyphenols were detected in non-hydrolyzed rat plasma 0.5 hour after oral administration, and the concentration of rutin was 13.6 ± 3.65 nM. The metabolized compounds of kaempferol sulfoglucuronide and 3'-O-methylquercetin sulfoglucuronide were identified by exact mass determination and exact mass mass spectrometry/mass spectrometry (MS/MS) in the plasma of rats fed a 5 % Ukogi diet for 8-24 days. Antioxidant potential of the metabolized compounds is discussed concerning a beneficial effect in the body via antioxidation caused by not only scavenging superoxide but also blocking superoxide generation.
著者関連情報
© 2013 Society for Science and Technology

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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