1999 年 48 巻 2 号 p. 144-148
This study was conducted to investigate a sequential prevention method for paresthesia of the mental nerve that is a complication of sagittal split ramus osteotomy (SSRO). To investigate the effects by maintaining the blood flow to of the peripheral nerve, Prostaglandin E1 (PGE1) was administered intravenously during SSRO.
Trigeminal somatosensory evoked potential (TSEP) was monitored intraoperatively and postoperative paresthesia was examined to evaluate the disturbance in nerve function. Twenty-eight nerves of 14 patients who were administered PGE1 (PGE1 group) were compared statistically with 22 nerves of 12 patients who were not administered PGE1 (no PGE1 group). Disappearance of TSEP waves were observed in 11 of 28 nerves in the PGE1 group, and 16 of 22 nerves in the no PGE1 group. Postoperative paresthesia on the next day was recognized in 11 of 28 nerves in the PGE1 group, and 17 of 22 nerves in the no PGE1 group. Comparison showed a significant difference between the two groups (p<0.01). No patients endured paresthesia for a long time (over 6 months) in the PGE1 group. The incidence of disturbance in nerve function was low and the period of paresthesia was short in the PGE1 group.
It was suggested that PGE1 can reduce paresthesia of the inferior alveolar nerve caused by SSRO.