巻号一覧
48 巻 (1999)
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48 巻, 2 号
選択された号の論文の9件中1～9を表示しています
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佐藤 明1999 年 48 巻 2 号 p. 105-115
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーThe purpose of this study was to investigate expression of matrix metalloproteinase activities (MMP-2 and -9) during DMBA-induced carcinogenesis of hamster buccal pouch, as well as in biopsy specimens of oral leukoplakia and squamous cell carcinoma. In buccal mucosa of hamsters, there was no significant increase in MMP-2 activity during the development of DMBA-induced carcinomas as compared with normal mucosa. In contrast, there was a significant increase in MMP-9 activity during the development of carcinomas. In addition, the increase in the MMP-9 activity was seen as the size of the carcinomas increased. The expressions of these matrix metalloproteinases were observed in epithelial cells and stroma cells according to a microdissection study. On the other hand, elevated levels of MMP-9 were also observed in squamous cell carcinomas in comparison with oral leukoplakia using zymography and immunohistochemistry.
The results suggested that the expression of MMP-9 might be one of the positive markers for malignant potential of oral premalignant lesion.抄録全体を表示PDF形式でダウンロード (5212K) -
川崎 五郎, 柳本 惣市, 陶山 一隆, 水野 明夫1999 年 48 巻 2 号 p. 116-120
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーIn the previous report, Anneroth's classification for squamous cell carcinoma of the oral region was useful for prognosis. The purpose of this study was to examine the expression of Ki-67 and its correlation with Anneroth's classification in human tongue carcinoma.
The present study included 40 patients with proven squamous cell carcinoma of the tongue. Ki-67 staining was carried out using the strepto-avidin-biotin complex method and the counts were recorded per 1000 tumour cells. The mean Ki-67 index was 18.2 %. The minimum staining was 4.2 %, and maximum 38.9%. The Ki-67 index failed to correlate with any clinical factor. There was significant correlation between the Ki-67 indices of the Anneroth's histological malignancy grade which were divided into three degrees by total points of 6 parameters. In the degree of keratinization, pattern of invasion and stage of invasion, there was significant correlation between the Ki-67 indices of each histologic grading of malignancy. On the other hand, in nuclear polymorphism, the number of mitoses and lymphoplasmocytic infiltration, there was no correlation between the Ki-67 indices of each histologic grading of malignancy.抄録全体を表示PDF形式でダウンロード (1768K) -
徳川 友希, 代田 達夫, 宝田 三恵, 山崎 正貴, 本橋 征之, 大野 康亮, 道 健一, 山口 朗1999 年 48 巻 2 号 p. 121-133
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーThis study was conducted to investigate the effects of estrogen replacement on bone reaction after installation of an implant into the tibiae of ovariectomized rats. Twelve-week-old female Wistar rats were divided into 3 groups of 25 animals each. The first group (Sham) underwent sham operation, the second group (OVX) ovariectomy only, and the third group (OVX + E) ovariectomy and administration of continuius estrogen with a 17β-estradiol pellet. Titanium screw implants were placed in the proximal metaphyses of the tibiae 168 days after surgery. The animals were sacrificed 7, 14, 28, and 56 days after implantation. Undecalcified sections were prepared and evaluated by light microscopy. Histomorphometric measurements were obtained with a computerbased image analyzer to quantify the unit bone mass around the implant and the rate of implant-bone conact.
Ovariectomy significantly reduced implant-bone contact and bone volume around the implants. However, in the OVX -FE group, only a slight difference in both bone contact and bone volume was noted compared with the Sham group. These results suggested that estrogen replacement prevented decrease of the implant-bone contact and the bone volume around implants in the tibial metaphyses of ovariectomized rats. Therefore, estrogen replacement therapy is useful to prevent reduction of bone attributable to surrounding dental implants that may occur with estrogen deficiency in postmenopausal patients.抄録全体を表示PDF形式でダウンロード (5133K) -
田中 良男, 原田 利夫, 内藤 晋一, 吉村 安郎1999 年 48 巻 2 号 p. 134-137
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーSurgery has been the most common treatment for mucous retention cyst of minor salivary glands, but occasional recurrence is observed after operation.
Alginate impression material has been used during surgery as an aid for defining the margins of lesions.
The purpose of this study was to assess the usefulness of alginate impression material for treatment of mucous cyst of the oral floor, focusing particularly on whether it is possible to sterilize and whether it can harden sufficiently for practical use, and the rate of lesion recurrence after use and nonuse thereof.
Three commercially available alginate impression materials were sterilized by ethylene oxide gas, and sterilization retarded the hardening in comparison with unsterilized materials. When the mucous contents were exchanged by alginate impression paste, the recurrence rate was diminished remarkably. The results indicated that alginate impression paste clearly delineates a mucous cyst from the surrounding normal tissue and tends to stabilize the soft tissues, making operation easier. This exchange method was found to be clinically useful.抄録全体を表示PDF形式でダウンロード (1576K) -
角田 博之, 岩渕 博史, 角田 和之, 高森 康次, 永井 哲夫, 田中 陽一1999 年 48 巻 2 号 p. 138-143
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーA 28-year-old male with polyps on the bilateral tongue margin following bone marrow transplantation for chronic myelogenous leukemia was reported.
This disease was difficult to diagnose and to treat, because the polyps grew very rapidly and were suspected to be malignant. In this case, severe oral mucositis was noted till day 58 after bone marrow transplantation. The patient developed chronic graft for the host disease on day 100, and the polypoid tongue lesions were subsequently observed. An excisional biopsy was performed, and histopathologic examination of the specimen revealed granulation tissue which was compatible with the criteria of c-GVHD. Based on the results as well as those of previous reports, it was suggested that the granulation tissue could occur on non-gingival soft tissue following bone marrow transplantation.抄録全体を表示PDF形式でダウンロード (1764K) -
第2報: プロスタグランジンE1による防止効果について青木 伸二郎, 堀本 進, 斉藤 友克, 水木 信之, 筑丸 寛, 藤田 浄秀1999 年 48 巻 2 号 p. 144-148
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーThis study was conducted to investigate a sequential prevention method for paresthesia of the mental nerve that is a complication of sagittal split ramus osteotomy (SSRO). To investigate the effects by maintaining the blood flow to of the peripheral nerve, Prostaglandin E1 (PGE1) was administered intravenously during SSRO.
Trigeminal somatosensory evoked potential (TSEP) was monitored intraoperatively and postoperative paresthesia was examined to evaluate the disturbance in nerve function. Twenty-eight nerves of 14 patients who were administered PGE1 (PGE1 group) were compared statistically with 22 nerves of 12 patients who were not administered PGE1 (no PGE1 group). Disappearance of TSEP waves were observed in 11 of 28 nerves in the PGE1 group, and 16 of 22 nerves in the no PGE1 group. Postoperative paresthesia on the next day was recognized in 11 of 28 nerves in the PGE1 group, and 17 of 22 nerves in the no PGE1 group. Comparison showed a significant difference between the two groups (p<0.01). No patients endured paresthesia for a long time (over 6 months) in the PGE1 group. The incidence of disturbance in nerve function was low and the period of paresthesia was short in the PGE1 group.
It was suggested that PGE1 can reduce paresthesia of the inferior alveolar nerve caused by SSRO.抄録全体を表示PDF形式でダウンロード (784K) -
森寺 邦康, 岸本 裕充, 高橋 由美子, 柳澤 高道, 浦出 雅裕1999 年 48 巻 2 号 p. 149-152
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーA case of orbital cellulitis subsequently occurring due to odontogenic sinusitis is reported. A 24-yearold male was admitted to our hospital complaining of severe pain and swelling of the right orbital region.
The patient was unable to open his right eye and had diplopia and hypoesthesia in the right maxillary region. On radiographic examination, cystic radiolucent area of the right upper molar region and increased radiopacity on the right maxillary sinus indicated odontogenic sinusitis. Computed tomography showed exophthalmus and inflammation of the maxillary and ethmoid sinuses extending to the orbit. The inflammatory symptoms, including exophthalmus and diplopia, were improved by the systemic antibiotic administration of PAPM / BP and tooth extraction of the right upper second and third molars without complication.抄録全体を表示PDF形式でダウンロード (1446K) -
高橋 雅幸, 黒川 英人, 安藤 俊史, 佐藤 泰則, 埜口 五十雄1999 年 48 巻 2 号 p. 153-158
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーSurgical treatment for buccal cancer in a 63-yearold male who had received hemodialysis for 10 years was performed.
Preoperative examination revealed that he had choronic hepatitis C, mitral regurgitation and hypertension. He had undergone tumor excision and reconstruction with a pectoralis major myocutaneous flap.
Due to careful management, it was an uneventful operation.
Postoperatively, hyperkalemia, hypoproteinemia, anemia and partial necrosis of the flap occurred, but were alleviated with appropriate management including urgent hemodialysis.
The patient's prognosis was good for 8 months after the operation, but he died suddenly from pneumonia in another hospital.
There have been few reports on operations for oral cancer in hemodialysis patients. This experience was very significant.抄録全体を表示PDF形式でダウンロード (3349K) -
野内 一嘉, 高橋 喜久雄, 吉野 智晴, 古谷 隆則, 丹沢 秀樹, 佐藤 研一1999 年 48 巻 2 号 p. 159-163
発行日: 1999/03/10
公開日: 2011/09/07
ジャーナル フリーOral manifestations of two patients with idiopathic hypoparathyroidism were evaluated after administration of vitamin D3 for ten years. One patient had enamel hypoplasia on the bilateral premolars of the maxilla and mandible. The other patient showed shortened roots and thickening of the lamina dura of the mandibular molars by radiographic examination.
The onset of hypocalcemia could be surmised from these findings. Neither anomalies of the maxillofacial bone nor delay development of the extremities could be observed. It was considered that continuous low levels of parathyroid hormone did not effect the development of teeth after administration of vitamin D3 because the dental anomalies were localized completely in the specific teeth.抄録全体を表示PDF形式でダウンロード (1678K)
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