Several telomers obtained by the palladium catalyzed telomerization of butadiene with nucleophiles have functionalities suitable for simple synthesis of certain macrolides. A new method of lactone formation based on intramolecular alkylation of a carbanion generated by phenylthio group was used for the macrolide syntheses. The 12-membered Recifeiolide was synthesized from 9-nitro-1,6-decadiene obtained by the telomerization of butadiene and nitroethane. The telomer of butadiene and acetic acid was used for the synthesis of the 12-membered Lasiodiplodin and the 10-membered Diplodialides. Also a model compound of the 14-membered Zearalenone was synthesized.
