抄録
Natural products from marine invertebrates such as sponges or tunicates are attractive sources of drugs because of their unique structure and bioactivity. However, a critical obstacle in the development of these compounds is the problem of supply. Neither chemical synthesis nor mariculture of invertebrates are economically feasible in most cases. Due to the similarity of structures, a large part of marine natural products are suspected to be produced by the associated microorganisms. Therefore, production of these compounds by a culturable microorganism is one of favarable strategies. Here we report that didemnin B, a tunicates-derived depsipeptide, was isolated from a culturable microorganism, Mt-rolls mobilis YIT 12409. Purification of the extract of culture broth yielded didemnin B. The compound identification was conducted by MS and NMR spectroscopy and optical rotation analysis. Taxonomic identification was determined by 16S rRNA analysis.
