The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Regular Contributions
Hypoxic Effects on Cholesterol Metabolism of Cultured Rat Aortic and Brain Microvascular Endothelial Cells, and Aortic Vascular Smooth Muscle Cells
Yukio Arai, Masayuki Sasaki, Norio Sakuragawa
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キーワード: hypoxia, cholesterol metabolism, brain microvascular endothelial cells, atherosclerosis
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1996 年 180 巻 1 号 p. 17-25

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We investigated hypoxic effects on cholesterol metabolism in cultured brain microvascular endothelial cells (BEC), aortic endothelial cells (AEC) and aortic vascular smooth muscle cells (VSMC) from rat. In control conditions, acid lipase activities in BEC and AEC were higher than that in VSMC. Acyl-Coenzyme A: cholesterol acyltransferase (ACAT) activities in control cells of BEC and AEC were lower than that of VSMC. Hypoxic treatment caused decreased acid lipase activity. ACAT activity decreased in VSMC. High pressure lipid chromatography (HPLC) study showed that hypoxia caused decreased contents of cholesterol and cholesteryl esters especially in AEC. We suggested that there is different cholesterol metabolism in the hypoxic treatment among endothelial cells and smooth muscle cells.
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© 1996 Tohoku University Medical Press
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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