抄録
To know whether the insulin resistance is improved by delaying carbohydrate absorption from the small intestine, we studied the effect of a disaccharidase inhibitor, AO-128, on insulin resistance of Wistar fatty rats. Rats were kept on standard laboratory chow with and without 10 ppm of AO-128 for 4 weeks, and then subjected to the glucose clamp. At the end of the 4-week treatment, plasma glucose level at 14 : 00 to 16 : 00 of AO-128 treated rats was 121±14 mg/100 ml (mean±S.D.), significantly lower than 226±72 mg/100 ml of the rats without AO-128. During clamp steady state under 20 mU·kg−1 continuous insulin infusion, glucose uptake of AO-128 treated rats was only 7.62 ± 0.70 mg. kg−1. min−1, not different from 6.64±0.91 mg·kg−1·min−1 of rats without AO-128, but much lower than the lean littermates (20.81±3.11 mg·kg−1·min−1). However, the percent suppression of hepatic glucose output was 55.2±23.8%, which, though incomplete, was significantly higher than 17.4±11.2% of rats without AO-128. The present study suggested that there were at least two, components of insulin resistance, a genetically determined and a poor-glycemic control-related, and that the latter insulin resistance was ameliorated by AO-128.
