The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
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Investigation of Intracellular Factors Involved in Methylmercury Toxicity
AKIRA NAGANUMATAKEMITSU FURUCHINOBUHIKO MIURAGI-WOOK HWANGSHUSUKE KUGE
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2002 Volume 196 Issue 2 Pages 65-70

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Abstract

Methylmercury is a known pollutant that causes severe central nervous system disorders. It is capable of passing through the blood-brain barrier and accumulates in cerebral cells. However, little is known regarding the mechanism of its toxicity at the molecular level. Using yeast cells, we searched for the genes involved in the expression of methylmercury toxicity, and found that genes encoding L-glutamine·D-fractose-6-phosphate amidotransferase (GFAT) and ubiquitin transferase (Ubc3) confer methylmercury resistance on the cells. It has also been shown that GFAT is the target molecule of methylmercury in yeast cells. These findings provide important clues about the mechanism underlying methylmercury toxicity ini mammals.

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© 2002 Tohoku University Medical Press
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