The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Invited Review
The Role of the Thymus in the Pathogenesis of Myasthenia Gravis
Hiroshi Onodera
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Keywords: chemokine, myasthenia gravis, thymus
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2005 Volume 207 Issue 2 Pages 87-98

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Abstract

Myasthenia gravis is an organ-specific autoimmune disease characterized by the production of anti-acetylcholine receptor antibodies. In this review, I describe the pathophysiological importance of the altered chemokine receptor-mediated signaling in the thymus and peripheral blood of myasthenia gravis patients. The epidemiological and clinical features of myasthenia gravis are also discussed.

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© 2005 Tohoku University Medical Press
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