The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Free Amino Acid Pattern in the Brain from Rats with Hyperaminoacidemia
KEIYA TADA, GORO TAKADA, TSUNEO ARAKAWA
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キーワード: amino acids in brain, hyperaminoacidemia
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1971 年 103 巻 1 号 p. 49-59

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Hyperaminoacidemia was induced in 17-day-old rats by intra-peritoneal injection of a single amino acid and the free amino acid pattern in the brain was analyzed at 1 hour after the injection. A significant alternation of the free amino acid pattern in the brain was observed by the loading of phenylalanine, histidine, valine, methionine or glycine, respectively. These findings suggest that the inhibition of amino acid transport by excess of a single amino acid may result in decrease of essential amino acids and in reduced rate of brain protein synthesis.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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