The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
A Comparative Ultrastructural Study on Druginduced Proliferation of Smooth-surfaced Endoplasmic Reticulum in Hepatocytes
BHAGWAN D. GARG, JOSEPH A. BLASCHECK, KALMAN KOVACS
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Keywords: phenobarbital, methylcholanthrene, catatoxic steroids, SER proliferation, enzyme induction, liver
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1971 Volume 104 Issue 3 Pages 205-214

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Abstract
In rats, administration of phenobarbital, 3-methylcholanthrene, spironolactone, cyproterone acetate or pregnenolone-16a-carbonitrile causes proliferation of the smooth-surfaced endoplasmic reticulum (SER) in hepatocytes, without producing marked changes in other cell organelles. The significance of this SER increase and its relationship to microsomal enzyme induction are discussed.
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