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Volume 104 (1971)
- Issue 4 Pages 305-
- Issue 3 Pages 205-
- Issue 2 Pages 105-
- Issue 1 Pages 1-
Volume 104, Issue 3
Displaying 1-8 of 8 articles from this issue
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BHAGWAN D. GARG, JOSEPH A. BLASCHECK, KALMAN KOVACS1971 Volume 104 Issue 3 Pages 205-214
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn rats, administration of phenobarbital, 3-methylcholanthrene, spironolactone, cyproterone acetate or pregnenolone-16a-carbonitrile causes proliferation of the smooth-surfaced endoplasmic reticulum (SER) in hepatocytes, without producing marked changes in other cell organelles. The significance of this SER increase and its relationship to microsomal enzyme induction are discussed.View full abstractDownload PDF (4605K) -
SHOJI YAMADA, YASUKO YOKOYAMA, SHUICHI KIMURA1971 Volume 104 Issue 3 Pages 215-223
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFor the purpose of elucidating the physiological significance of intrinsic factor (IF) in vitamin B12 absorption, comparative studies on the adsorption of vitamin B12 to intestinal mucosa homogenate of unweaned (aged 48 hours old) and adult rats were carried out. Any material having IF activity on the intestine of the adult rat and the unweaned rat was not secreted from the stomach of the unweaned rat. This result was confirmed by the histologic findings that the chief cells of the unweaned rat, when examined on the fundus portion of the stomach, were still undeveloped. The adsorption of vitamin B12 to the intestinal mucosa homogenate of the unweaned rat seemed to be independent on the IF and the presence of Ca++ ion. The amount of vitamin B12 adsorbed to intestinal mucosa homogenate of the unweaned rat, as expressed by μg vitamin B12/kg body weight, was from 4 to 10 times larger than that of the adult rat. The high capacity of the intestinal mucosa homogenate of the unweaned rat to adsorb vitamin B12, regarded as the first step of vitamin B12 absorption, may be related to the fact that unweaned rat can absorb a large amount of vitamin B12. The small intestine of the unweaned rat appears to take indiscriminately fairly large molecules. The results of the experiments which investigated the effects of bivalent cations on the adsorption of vitamin B12 to intestinal mucosa homogenate suggested that the so-called sequential uptake might have occurred.View full abstractDownload PDF (1335K) -
KATSUMI MURATA, KOJI NAKAZAWA1971 Volume 104 Issue 3 Pages 225-232
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSerum lipid changes were investigated following a drug shock and 16 intoxication cases. Analyses of serum lipid fractions showed that both drug shock and intoxication resulted in a demonstrable decrease of triglyceride and a trend of increase of phospholipid. The elevated ratio of phospholipid to triglyceride was shown to be closely associated with the severity of the clinical manifestation. It was suggested that the elevation of phospholipid to triglyceride ratio could be used as a feasible index to evaluate and follow cases of shock and intoxication. No appreciable changes were found in serum hexosamines and cholesterols except in a deceased case in which the latter reduced to less than 70mg/100ml.View full abstractDownload PDF (348K) -
TAKEOKI MINETA, EIAKI TSUTSUMI, HIROSHI SUZUKI, MORIO KASAI1971 Volume 104 Issue 3 Pages 233-249
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSElectrolyte disturbances, especially hypernatremia, which are not uncommon in cerebral injuries or diseases, are usually attributed to water depletion and sodium retention. The authors observed hypernatremia in 9 of 37 neurosurgical patients. In 2 of them, water depletion and sodium retention were denied by the balance study and estimation of the sodium space and total exchangeable sodium, and hypernatremia was considered to be due to damage to the central nervous system itself. Experimental injury of the brain also caused hypernatremia in 3 of 44 dogs. Analysis of tissue electrolytes suggested the shift of electrolytes between intra- and extracellular compartments. Decrease of muscle sodium was comfirmed in these patients, while bone sodium did not change. Release of muscle sodium was regarded as contributing to hypernatremia.View full abstractDownload PDF (819K) -
SEIGI TSUCHIDA1971 Volume 104 Issue 3 Pages 251-262
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSNephrostomy was performed in dogs for the purpose of taking electroureterograms free from any influence of changes in urine flow. At the same time, either the renal artery and vein were ligated, or only the renal vein was ligated, and isoproterenol was injected in the latter cases. In each case electroureterograms were recorded. The results obtained are as follows. 1) When nephrostomy was performed, the influence of changes in the urine flow could be excluded in cases of oliguria, but not in cases of polyuria. 2) When the renal artery and vein were ligated, the discharge interval of action potential became extended. 3) When only the renal vein was ligated, the influence of ligation was hardly observed on the electroureterogram. 4) When the renal vein alone was ligated and isoproterenol was administered by intra-aortic injection, the action potential ceased transitionally.View full abstractDownload PDF (3667K) -
GEN NIWAYAMA, VIBUL V. VADAKAN1971 Volume 104 Issue 3 Pages 263-287
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThree cases of congenital cardiac anomalies involving the Eustachian valve are presented. The first is a case of a 12-year-old boy with findings of severe chronic myocarditis combined with an anomalous Eustachian valve which divided the right atrium and caused moderate constriction of the inferior veana cava orifice, resulting in marked congestion of the intraabdominal viscera. The second case, a 30-day-old male infant, exhibited an area of aneurysmal dilatation in the midportion of the Eustachian valve associated with interventricular septal defect and right aortic arch. The third case, a 9-month-old male child with interventricular septal defect, transposition of the great vessels, bicuspid pulmonic valve and anomalous origin of the left subclavian artery, had an abnomrally enlarged, membranous Eustachian valve. A review of similar anomalies reported in the literature and of the classification of minor variations and major anomalies is presented.View full abstractDownload PDF (2986K) -
GEN NIWAYAMA, VIBUL V. VADAKAN1971 Volume 104 Issue 3 Pages 289-300
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn a necropsy analysis comprising 26 male and 15 female infants with intestinal obstruction, 18 (44%) were found to have associated fibrocystic disease of the pancreas. The co-occurrence of these two conditions was most frequent when the obstruction was located in the jejunum, ileum or colon and least significant when the duodenum was the site of involvement. Meconium was present in most cases beyond the site of obstruction. Peritonitis was a frequent complication. Pulmonary involvement was common. A significant proportion of our cases showed congenital malformations.View full abstractDownload PDF (1461K) -
JUNICHI SUWA, SHUICHI KIMURA, TATSUO KOYANAGI1971 Volume 104 Issue 3 Pages 301-304
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSHourly changes of 131I uptake and the changes in several indices of thyroid at different time intervals after beginning of an iodine deficient diet with or without propylthiouracil were determined. An amino acid mixture was used as the protein source in the present experiments. The magnitude of iodine uptake and the ratio of monoiodotyrosine to diiodotyrosine increased according to the length of time on low iodine diet. The earlier appearance and more enlargement of peak of the ratio of monoiodotyrosine to diiodotyrosine in rats treated with small dose of propylthiouracil than in those untreated suggested that propylthiouracil might also bring about the lack of iodine by inhibiting the iodination at substrate level.View full abstractDownload PDF (223K)
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