Abstract
Incorporation of CDP-choline-1, 2-14C into phosphatidylcholine by brain homogenate and microsome was found to be higher than that of liver before and during active myelination period in rats. Incorporation of S-adenosylmethionine-methyl-14C into phosphatidylcholine by brain microsome was about 1/20 of that by liver microsome in two-week-old rats. These results indicate that in developing rat brain, phosphatidylcholine may be synthesized by transmethylation, to some extent, in addition to the major pathway via CDP-choline.
