Responses of Plasma LH to Insulin-induced Hypoglycemia, Vasopressin, Premarin and Clomiphene
キーワード:
LH,
regulation of LH release
1971 年 105 巻 1 号 p. 65-74
詳細
1971 年 105 巻 1 号 p. 65-74
Responses of plasma LH to various stimuli were studied in order to evaluate a pituitary reserve of LH in normal subjects and in patients with various endocrine disorders. Plasma LH levels were determined by coated charcoal radioimmunoassay. Basal fasting levels of plasma LH in 22 normal men ranged from 7 to 55μg/100ml (LER 907) with a mean of 23. The variations of plasma LH in 6 normal subjects in 2 hours from 7: 30 to 9: 30a. m. were within 12μg/100ml. Treatments of normal subjects with insulin-induced hypoglycemia (regular insulin 0.1U/kg body weight i. v.), lysine-8-vasopressin (7 PU i. v. over 60min), Premarin (20mg i. v.) and clomiphene citrate (150mg/day by mouth for 3 days) resulted in significant rises of plasma LH in most of the subjects. Patients with panhypopituitarism showed no response of plasma LH to these stimuli and patients with Turner's syndrome and patients with idiopathic precocious puberty showed exaggerated responses.
