Cholinergic Spontaneous Junctional Potentials in Guinea-pig Vas Deferens

Abstract

Spontaneous junctional potentials (SJP) in guinea-pig vas deferens were investigated with intracellular microelectrodes. In some of the cells examined, SJP was atropine-sensitive and presumably cholinergic in nature. This finding stands in contrast to the generally accepted concept that all of SJPs in vas deferens are atropine-resistant and noradrenergic in nature. It seems more likely from this result that there exist two types of SJPs in vas deferens; one is noradrenergic type and the other is cholinergic type.