In two cases of idiopathic hypercholesterolemia, aged 6 and 12 years, it was found that in vivo incorporation of sodium acetate-1-
14C into serum cholesterol was markedly increased, but that into squalene and lanosterol in serum was less than that in controls.
In vitro incorporation of sodium acetate-
3H or DL-mevalonic acid-2-
14C into cholesterol was markedly increased in the liver homogenates from a patient with hypercholesterolemia, but it showed no difference between the patient and controls when skin, adipose tissue, bone marrow cells or leukocytes were used.
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