Effects of Metabolic Inhibitors on the Platelet Aggregation Induced by Hydrogen Peroxide

Abstract

In contrast to the adenosine diphosphate (ADP)-induced platelet aggregation, the hydrogen peroxide (H₂O₂)-induced platelet aggregation could be inhibited by either potassium cyanide or sodium azide or antimycin or oligomycin alone, suggesting that aerobic metabolism of glucose is essential to maintain a complete ability in aggregation of human platelets.