The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Decreased Hepatic Histidase Activity Induced by Diphenylhydantoin Administration as a Cause of Decrease in Urinary Formiminoglutamic Acid in Rats
TSUNEO ARAKAWA, YOSHIYUKI HONDA, KUNIAKI NARISAWA
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Keywords: histidase, FIGLU, diphenylhydantoin, folic acid
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1973 Volume 110 Issue 1 Pages 49-57

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Abstract
Decreased urinary excretion of FIGLU after an intraperitoneal injection of L-histidine monohydrochloride in rats with diphenylhydantoin admini-stration was partly resulted from a decreased activity of the hepatic histidase due to the drug administration.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.

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