The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Decreased Hepatic Histidase Activity Induced by Diphenylhydantoin Administration as a Cause of Decrease in Urinary Formiminoglutamic Acid in Rats
TSUNEO ARAKAWA, YOSHIYUKI HONDA, KUNIAKI NARISAWA
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Keywords: histidase, FIGLU, diphenylhydantoin, folic acid
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1973 Volume 110 Issue 1 Pages 49-57

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Abstract

Decreased urinary excretion of FIGLU after an intraperitoneal injection of L-histidine monohydrochloride in rats with diphenylhydantoin admini-stration was partly resulted from a decreased activity of the hepatic histidase due to the drug administration.

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