The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effect of “Substance R” on the Membrane Potential of Smooth Muscle Cell of Guinea-pig Taenia Coli
TSUNEHIKO S. SUZUKI, YASUE FUKUSHI, TAIZO SUZUKI
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Keywords: smooth muscle, Substance R
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1973 Volume 110 Issue 4 Pages 407-408

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Abstract
Substance R is a new biologically active substance extracted from bovine brain. This substance caused the hyperpolarization of membrane potential of the smooth muscle of guinea-pig taenia coli. The time course of this hyperpolarization was considerably longer than that of noradrenaline or isoproterenol. This may suggest that the mechanism of hyperpolarizing effect of Substance R is different from that of catecholamines.
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